At the beginning Marquez took the lead followed by Andrea Iannone, the Ducati pair, Rossi and Dani Pedrosa. While wildcard entries Mika Kallio e Sylvain Guintoli crashed, Marquez, Lorenzo and Dovizioso escaped. The trio soon became a duo, as Dovizioso crashed out with 15 laps to go.
Lorenzo held an incredible pace (between 1:40.0 and 1:40.4 for most of the GP) and Marquez struggled a lot to stay close to him. More retirements to be reported: Xavier Simeon, Takaaki Nakagami, Bradley Smith, Franco Morbidelli and Hafizh Syahrin crashed, while Alex Rins and Tito Rabat had technical issues. The latter had to leave his bike in flames at Turn 1, after that the engine broke.
Finally, hammering Jorge Lorenzo grabbed his second win in a row in 2018 season, while Marc Marquez finished second ahead of Valentino Rossi. Cal Crutchlow ranked fourth after beating Dani Pedrosa. Maverick Viñales, Johann Zarco, Danilo Petrucci, Alvaro Bautista and Andrea Iannone closed the top 10.